How do I process eRx (e-Prescribing) refill requests?

Note: Access to the EHR features described in this article may differ for practices who have already purchased a Practice Fusion EHR subscription plan. Please contact Practice Fusion Customer Service for additional information.

Processing refill requests from the Tasks section
Once you start e-prescribing in Practice Fusion, pharmacies can send refill requests directly to your EHR account. Open the Refill requests tab of your Tasks list to review requests that have been assigned only to you or filter by Refill requests in the All tasks tab to see refills assigned to any prescriber in the practice.

Practice administrators can grant specific staff members who are Access Level 2 (Nurse) or higher the ability to match unassigned refill requests to patients in the practice, helping expedite the refill workflow. While all staff can view refill requests, only the original prescriber or eRx-enabled providers who have been granted the ability to approve or deny refills on behalf of another provider can process them. To learn more about prescription task delegation, click here.

Approving a refill request
1. To process a refill request, click Review in your Tasks List.

2. The system will find the appropriate patient; you will simply need to select Assign and Save. Alternatively, search for a different patient. If staff member has been granted permission, they can also assign the request to a patient.
3. Review the request to ensure that all information is accurate. Where applicable, Practice Fusion will show you new drug interaction alerts based on recent changes to the patient’s medication list.

4. You have the option to either confirm or update the number of refills and match the refill to an existing medication in the patient’s chart if it was not already matched. Although you may send a custom note using the Note to pharmacy field, to prevent processing delays, this field should not contain redundant or conflicting information that has already been entered as part of the prescription.  

5. Once you have reviewed the request, click Approve. The refill will be sent to the pharmacy and will be recorded in the patient’s Timeline. If a provider has approved a refill request on behalf of another provider, both the original and approving prescriber will be listed.

Denying a refill request
There are some instances in which you’ll deny a refill request. These instances may include when the script has already been refilled by phone or fax or when the patient needs an appointment before a refill is provided. 

1. To deny a refill request, click Review in your Tasks List.

2. Select a reason for denial and click Deny.

There are other instances in which you receive a refill request but you need to write a new script. These instances may include when you want to modify the dose or quantity, or if the refill request is for a controlled substance. In this case, follow the steps below: 

1. Select a Reason for denial.

2. Click the arrow next to Deny and select Deny, script to follow.


3. You will be prompted to create a new prescription in patient’s chart. If the Deny Refill, Script to Follow option is selected, some pharmacies' software will push this new request to the top of their queue so that patients waiting for a refill can receive their medications quicker.


  1. How do I sign up for eRx (e-Prescribing)?
  2. How do I send an eRx (e-Prescription)?
  3. How do I process eRx (e-Prescribing) refill requests?
  4. How do I prescribe multiple medications in a single order?
  5. How do I search for a pharmacy or enter a preferred pharmacy?
  6. Why am I unable to send an eRx (e-Prescription)?
  7. What do eRx (e-Prescribing) error messages mean?
  8. Activating e-prescribing of controlled substances (EPCS): Step 1 of 2
  9. Setting up EPCS e-signing permissions: Step 2 of 2
  10. How do I send e-prescriptions (eRx) and approve refills for controlled substances?
  11. How do I enable and use prescription task delegation?
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  13. What is the status of my eRx (e-Prescribing) request?
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  16. How do I add my NPI and DEA numbers to printed prescriptions?
  17. Can I be enabled for e-prescribing on two Practice Fusion accounts at the same time?
  18. How do I edit a refill sent by the pharmacy?
  19. Can I e-Prescribe through multiple eRx vendors?
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  26. How do I re-activate eRx (e-Prescribing)?
  27. How can I help a provider verify eRx (e-Prescribing) credentials?
  28. How can I disable refill requests?
  29. How do I update my phone or fax number for eRx (e-Prescribing)?
  30. Who can send an e-prescription?
  31. Why am I not receiving eRx (e-Prescribing) refills?
  32. What if I fail e-Prescribing (eRx) verification?
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  34. How do I use electronic prior authorizations?
  35. How do I print an e-Prescription receipt?
  36. How do I use medication adherence?
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  38. How can I see medication costs and cost-saving alternatives?
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  43. How do I submit prior authorizations via Physicians’ Desk Reference (PDR)?
  44. How do I update the Authenticator application for EPCS?
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