How does I-STOP affect my practice and what is Practice Fusion doing to prepare for EPCS?

We’re excited to announce our certified e-prescribing for controlled substances (EPCS) feature is available to practices in New York State.

We released our EPCS feature to practices in New York so that appropriately licensed providers can e-prescribe controlled substances from their EHR before the I-STOP deadline. For additional information, please see: How do I activate e-prescribing of controlled substances (EPCS) for I-STOP: Step 1 of 2?

I-STOP Overview
As of August 27, 2013, New York practitioners are required to check the Prescription Monitoring Program (PMP) Registry prior to writing a prescription for a Schedule II, III, and IV controlled substance. In order to access the PMP Registry, a practitioner must first have a Health Commerce System (HCS) account.

A practitioner may authorize a designee to consult the PMP Registry on his or her behalf, provided that the:
• Designee is employed by the same professional practice as the authorizing practitioner;
• Practitioner takes reasonable steps to ensure that the designee is competent in the use of the PMP Registry;
• Practitioner remains responsible for ensuring that access to the PMP Registry by the designee is limited to authorized purposes and protects the confidentiality of the information; and
• Decision as to whether or not to prescribe a controlled substance remains solely with the practitioner.

In addition to consulting the PMP Registry prior to sending a prescription for Schedule II, III and IV medications, providers of controlled substances must transmit prescriptions electronically as of March 27, 2016.

The certified EPCS software application must be registered and renewed with the Bureau of Narcotic Enforcement (BNE) at least every two years or as the DEA requires a new third-party audit of the EPCS software application, whichever occurs first. There is no need to register e-prescribing software that only transmit non-controlled substances prescriptions, although you are still required to use a certified e-prescribing system that meets all applicable rules and regulations for such purposes.

The ROPES (Registration for Official Prescription and e-Prescribing Systems) application will allow practitioners to update/certify/renew their Official Prescription Program (OPP) registration and register or modify their certified electronic prescribing software application for controlled substances (EPCS software) at the same time. To register for an OPP account, a practitioner must first register with OPP by submitting registration form DOH-4329 to the BNE. Please note that only practitioners may access ROPES.

When registering Practice Fusion as your EPCS software, you will be required to enter the following information:
• Name of certified e-prescribing software application: Practice Fusion EHR
• Software version certified: 3.6
• Name of software application provider (company name): Practice Fusion, Inc.

Prior to registering the certified EPCS software application with BNE, each practitioner must complete Practice Fusion’s identity proofing and medical credential verification procedures, and obtain two-factor authentication for use with EPCS. For detailed information on completing this process, please see: How do I activate e-prescribing of controlled substances (EPCS) for I-STOP: Step 1 of 2?

The following resources can help providers understand the requirements of I-STOP that they are responsible for:

NY Department of Health FAQ page on PMPR and registering for a HSC account
New York Chapter of American College of Physicians page on I-STOP
NY Department of Health PMP Brochure for Practitioners and Pharmacists
Instructions to the PMP registry


  1. How do I sign up for eRx (e-Prescribing)?
  2. How do I send an eRx (e-Prescription)?
  3. How do I process eRx (e-Prescribing) refill requests?
  4. How do I prescribe multiple medications in a single order?
  5. How do I search for a pharmacy or enter a preferred pharmacy?
  6. Why am I unable to send an eRx (e-Prescription)?
  7. What do eRx (e-Prescribing) error messages mean?
  8. Activating e-prescribing of controlled substances (EPCS): Step 1 of 2
  9. Setting up EPCS e-signing permissions: Step 2 of 2
  10. How do I send e-prescriptions (eRx) and approve refills for controlled substances?
  11. How do I enable and use prescription task delegation?
  12. How do I print and format prescriptions?
  13. What is the status of my eRx (e-Prescribing) request?
  14. Prescription Formulary FAQ's
  15. How do I edit my Drug-Drug and Drug-Allergy Interactions Settings?
  16. How do I add my NPI and DEA numbers to printed prescriptions?
  17. Can I be enabled for e-prescribing on two Practice Fusion accounts at the same time?
  18. How do I edit a refill sent by the pharmacy?
  19. Can I e-Prescribe through multiple eRx vendors?
  20. How do I add a pharmacy to the database?
  21. How can I discontinue a medication?
  22. How can you see the status of an eRx (e-Prescription)?
  23. How does I-STOP affect my practice and what is Practice Fusion doing to prepare for EPCS?
  24. What does the eRx (e-Prescribing) "Pending" status mean?
  25. How do I disable my e-prescribing with Practice Fusion?
  26. How do I re-activate eRx (e-Prescribing)?
  27. How can I help a provider verify eRx (e-Prescribing) credentials?
  28. How can I disable refill requests?
  29. How do I update my phone or fax number for eRx (e-Prescribing)?
  30. Who can send an e-prescription?
  31. Why am I not receiving eRx (e-Prescribing) refills?
  32. What if I fail e-Prescribing (eRx) verification?
  33. How do I use eCoupons?
  34. How do I use electronic prior authorizations?
  35. How do I print an e-Prescription receipt?
  36. How do I use medication adherence?
  37. Why am I receiving an alert to update my medical license?
  38. How can I see medication costs and cost-saving alternatives?
  39. What does it mean when a patient medication is no longer available?
  40. Ohio Prescription Instructions
  41. How does the Maine EPCS Opiates Mandate under L.D. 1646 affect my practice?
  42. How do I initiate a request for a prior authorization from the EHR?
  43. How do I submit prior authorizations via Physicians’ Desk Reference (PDR)?
  44. How do I update the Authenticator application for EPCS?
  45. Electronic Prescribing (eRx) and EPCS sign up with identity verification

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